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Wappapello Lake, MO is a 45,000-acre project nestled in the foothills of the Ozark Mountains on the St. Francis River in Southeast Missouri. Completed in 1941, Wapppapello Lake annually provides an estimated...[more]
Southeast Missouri. From St. Louis, travel south 32 miles on I-55 to U.S. 67. Continue south 88 miles to Greenville. Turn left on Highway D, travel south 20 miles.
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