Department of Transportation.
First tread by the hoofs of bison, Indiana's Historic Pathways has since become a route for pioneer exploration, stagecoach travel, and finally, modern highways. Drive along the Pathways, joining the lower Ohio Valley to the Mississippi Valley, and you'll be treated to rural countryside, rolling hills, memorable historic districts, peaceful forests, and a fuller understanding of Indiana's past.
Getting to the Byway:
Louisville International Airport, KY
Navigating the Byway:
* Begin at at the Indiana-Illinois border on US 50/US150. * Continue east through Shoals, IN. **North Spur** * From US 150/50 in Shoals, IN, continue northeast on US 50 through Lawrenceburg, IN to the Indiana-Ohio border. **South Spur** * From US 50/US150 at Shoals, IN, continue southeast on US 150 into New Albany, IN. * Continue east on local roads. * End at the Falls of the Ohio State Park in Clarksville, IN. (201 West Riverside Dr.)