Fish and Wildlife Service, Mississippi.
Established in 1978, Panther Swamp NWR is noted for its large waterfowl population, resident game and its numerous sloughs and wetlands. Although limited archaeological evidence exists about the earliest inhabitants of the Lower Mississippi Delta, early Native Americans probably hunted, fished, and even farmed much of the area now included in the boundaries of Panther Swamp National Wildlife Refuge. Unlike the more nomadic tribes of the northern and western plains, the Yazoo Indians built small villages and retreated into the loessal bluffs along present-day Yazoo City only when forced to by rising flood waters. Many raised “Indian Mounds” can still be found throughout the Delta.
From Jackson, MS
I-20 and I-55 exchange, travel northwest on I-20W toward Exit 43A. Slight right onto US-49N (signs for I-220 / N Jackson / Yazoo City) continue onto I-220 N. Take Exit 5B to merge onto US-49N / Delta Dr / Medger Evers Blvd toward Flora / Yazoo City. Continue to follow US-49N. From Flora Travel 22 miles on US-49N, turn left onto On MS-149 N / MS-16 W / Broadway St, continue to follow MS-149 N / MS-16W for 12 miles. Office is on the left.
From Belzoni, MS
Hwy 12 and US-49W S exchange, travel south on US-49W S 5 miles, turn right onto MS-149 S, travel 15 miles (From MS-14 E and MS-149 intersection, travel 5 miles). Office is on the right.